My research focuses on the development of safe and sustainable radiation-resist materials for space technology. Currently, NASA uses an organic material known as polyethylene as radiation shielding on-board the International Space Station. This work will expand on other organic materials which would be highly competitive radiation shielding materials in space. Aromatic-containing materials increase the structural stability compared to the already employed organic-based materials for radiation shielding. This work aims to engineer radiation resistant organic materials that can be used as coatings on space technology to prevent system malfunctions and degradation due to prolonged high ionizing radiation exposure by changing bonding networks within naphthalene-containing cocrystalline materials.
These cocrystalline materials have been reported to be tunable in their physical and chemical properties, providing us the capabilities to modify these materials for specific purposes such as increased structural stability and radiation resistance. Currently, I am comparing how changing the amount of aromaticity within naphthalene-based materials impacts the structural integrity of these materials when exposed to gamma radiation. Overall, these results will provide fundamental insights into rationally designing safe and sustainable radiation shielding materials for space technology coatings in the future.
Mason Henry – Iowa State University
My research project involves assisting Professor Matthew Nelson with engineering education through STEM engagement of K-12 students and teaching undergraduate students professional development skills such as time management, communication, decision-making, and adaptability. Working with the Make to Innovate high altitude balloon team, HABET, we are researching and carrying out new and innovative ways to get younger students involved with and excited about STEM through unique engineering experiences. This is done in hopes of engaging them to learn more about the fields included in STEM and to inspire the next generation of aeronautical innovators who will continue to transform the aviation industry, making it more sustainable and accessible. One of the ways this was achieved was by having kids under the age of thirteen participate in assisting with the launching of two balloons this past summer at the Iowa State Fair. As for the HABET team, they continue to develop their professional skillset by working with various clients ranging from physicists from the University of Iowa to the Food Sciences department here at Iowa State. I have aided in this development by coaching communication with clients and mentoring students in the decision-making process and adaptability between each client’s specific needs. Through high-altitude ballooning, this research falls unconventionally under the Aeronautic Research Directive due to its use of specific use of aeronautics in assisting with education research.
Gage Harris – Iowa State University
The objective of my Ph.D. research is to test the hypothesis that large-scale discrete multidisciplinary design optimization (MDO) can maximize complex, next-generation engineering systems’ performance automatically, which has not been possible with existing numerical methods. Specifically, I am looking at a new optimization framework considering low-thrust trajectory optimization with discrete fly-by options to enable more frequent and affordable missions, which aligns well with NASA’s mission to explore and extend our knowledge about the universe. MDO is a promising approach to tackle the above optimization because it can automatically use multiphysics simulations to find the best possible design, significantly reducing the design time. Existing gradient-based MDO algorithms can efficiently handle many design variables but cannot deal with discrete variables. In my PhD research, I will create a new large-scale discrete MDO framework (LSDMDO) to tackle the above challenge. LSDMDO is a novel class of optimization algorithms that efficiently synergize the gradient-based and evolutionary optimization methods to enable large-scale MDO problems with discrete variables. The LSDMDO algorithm will be rigorously derived, characterized, and evaluated in my PhD research.
Alexandra Grajales – Iowa State University
On Earth today, plants comprise the vast majority of fixed carbon in biomass and plant growth may be limited by bioavailable N. Studying the evolution of the terrestrial C cycle depends on understanding how plants fixed C and the availability of N in their environments. The relationship between C and N may reflect a combination of atmospheric isotopic signatures of CO2 and soil N availability. By cultivating plants in growth chambers with various CO2 and N2 fluctuating conditions, we can track plant adaptability and compare isotope plant tissue concentrations through time. I will periodically sample plant material throughout the experiment to track how plant growth can vary and how different concentrations of CO2 are stored within plant tissue. Also, I will track nitrogen and nutrient availability in the soil to understand the effect that strenuous conditions can have on the microbial communities that contribute to plant nutrient uptake. This research will allow for a deeper understanding of how plant tissues adapt to environmental changes in trying conditions and can be directly applied in growth chambers experiments done in space. It will open doors to studying plant adaptability and the minimal conditions needed for efficient plant growth on Earth and in space.
David Fehr – University of Iowa
Hannah Blumhoefer – Iowa State University
Abigail Whittemore – Drake University
A big concern for the health of astronauts and space crews is exposure to radiation and NASA lists “Risk of Radiation Carcinogenesis from Space Radiation” as one of its top research priorities. On Earth, we are protected from most space radiation by the atmosphere, but radiation increasingly affects those outside of Earth’s atmosphere and beyond low Earth orbit. Ionizing radiation damages DNA most commonly via phosphodiester backbone breakage. Humans can repair these damages, but prolonged exposure can lead to genomic instability and cancer. Thus, it is important to understand and monitor genome stability of astronauts during space travel. Therefore, our main goal is to develop biomarkers of radiation-induced DNA damage for monitoring genome stability of astronauts during and after space travel, thus contributing to safer space exploration. Previously, we have analyzed signal transduction DNA damage repair pathway genes in human mammary tumor cell lines. However, skin cancer is also a major concern due to radiation exposure, and understanding DNA repair pathways in skin cancer is equally important. Therefore, using the human skin cancer cell line HTB-72 and doxorubicin as a radiomimetic model, we will investigate how the oncoprotein BRAF responds to radiation-induced DNA damage. The data produced from this project will help us understand differences between the development of breast cancer and skin cancer.
Jonathan Percy – University of Iowa
Medical imaging serves a crucial role in establishing diagnosis, determining severity, monitoring progression, and uncovering the pathophysiology associated with many diseases. This research, led by Dr. Sean Fain, explores novel applications of hyperpolarized (HP) 129Xe magnetic resonance imaging (MRI) in populations including those suffering from Long Covid, cystic fibrosis, interstitial lung disease, and radiation-induced pulmonary changes associated with radiation therapy. This technique differs from standard imaging practices today while measuring lung function more directly than conventional pulmonary tests delivering quantitative measures of ventilation, perfusion, and gas exchange of the lungs. After more research, these novel biomarkers could possibly guide adjustments to treatment and deployment of potential therapies to improve outcomes.
Emma Pellegrino – University of Northern Iowa
Moonmilk is a white substance mainly composed of calcium carbonate (CaCO3) that is often found in limestone caves. It is one of many mineral composites in Wind Cave National Park South Dakota and is thought to be formed by microbial activity. Some of the evidence supporting this hypothesis lies in the association of metabolically active microorganisms in moonmilk such as Macromonas bipunctata, a bacterium first discovered in caves over a hundred years ago. More recently, there is evidence that dry versus wet moonmilk harbor different bacterial communities (Shanae et al., 2020). We have collected our own samples of moonmilk from different areas within Wind Cave using sterile supplies to avoid cross-contamination.
Each site had varying degrees of human exposure, from public tour routes to caverns only occasionally visited by park rangers. By extracting environmental DNA from these samples, we will then be able to measure microbial diversity. The resulting data set will allow us to estimate how much of the human microbiome transfers to moonmilk and whether there is a correlation between microbial diversity and the level of hydration in Wind Cave moonmilk. DNA will be extracted using the Qiagen PowerSoil Pro DNA Extraction kit followed by 16S rDNA PCR amplification and clone library construction to identify microbes. The results of this study will not only offer insights into the composition of microbial species in moonmilk, as well as their role in its formation, but will add to the larger genetic map of Wind Cave being constructed by the other students on my research team.
Gage MacLin – University of Iowa
This project aims to design and implement the guidance and control systems for various autonomous vehicles. Multi loop control will be used to calculate a trajectory that leads to a desired position, and then calculates the required actuation commands to reach that desired position. The work ahead lies in verifying the mathematical model of the vehicles, and then implementing various control theories and algorithms including adaptive control and trajectory tracking control. Once the control system is completed, it will be simulated extensively using MATLAB Simulink to prove robustness. Then, the control system will be implemented onto different autonomous vehicles for further testing.